This program is designed to cultivate clinical professionals with the requisite preparation for successful career development as independent investigators. The course provide a comprehensive overview and strong foundation of Clinical Research Methodologies, which will guide participants on how to design, conduct and document clinical research. The course will also provide an overview of ethical principles guiding clinical research. Course will be taught using a multi-disciplinary case-based pedagogical approach that will equip clinicians and basic science researchers interested in patient-oriented research to tackle health challenges currently faced by the country. The clinical research is broadly defined as patient-oriented, translational, epidemiological, comparative effectiveness, behavioral, outcomes, or health services research, or any other health related research where unit of observations include individuals human beings, or groups of human beings. The course will start with fundamental concepts, and essential vocabulary for designing and interpreting clinical research. Later during interactive sessions, case studies and real-world examples will be used to provide a deeper understanding of clinical research methodologies. Case-based methodologies will also be used to hone critical thinking and problem-solving skills. Finally with the project-based approach students will be able apply these concepts by creating a research protocol that is intended to address a relevant research question in their specific area of interest. The course is also intended to increase the technical proficiency in scientific writing by exposing students to different clinical sciences writing styles viz a viz manuscript writing, grant writing. The ultimate goal of this program is to prepare clinical professionals to be successful in clinical research.